Manchester City are looking to win their fourth consecutive Carabao Cup title.
Guardiola’s squad are on the verge of winning the Carabao Cup for the fourth consecutive time and six-time in eight years.
The Cityzens beat their noisy neighbours comfortably in a two-legged semi-final last season.
“My team won three times in a row. A semi-final for a fourth time in a row means a lot. If it would not be important we would have dropped it before,” Guardiola said.
“We cannot expect it to be more difficult than it should be with the rival we are going to face.
“United was above Manchester City and for us it is an incredible honour to be, over the last decade, there with them: sometimes win, most of the times, and lose some times.”
Kevin de Bruyne is yet to sign a new contract with City but Guardiola is not too concerned.
“I am pretty sure he will stay but at the same time we have to respect the process,” he told Sky Sports News.
“I don’t know what is going on as I didn’t speak with Txiki (Begiristain, City’s director of football).
“But he knows how we appreciate him, not just as a football player but as a person.
“He is very important for the club. I am not worried. But at the end of course it is his decision.”