Both Stones and Laporte will be unavailable for a week.
Aymeric Laporte and John Stones will be out for another seven days after missing out on the previous Champions League game against RB Leipzig.
The duo sustained a muscle injury whilst on international duty which could potentially rule them out for games against Wycombe and Chelsea.
City would have only two senior players in Ruben Dias and Ake available for these games.
“[They are] injured. [It’s] muscular,” Guardiola said at his pre-match press conference on Friday afternoon.
“John Stones didn’t play with us and then played 90 mins with national team and came back injured and Laporte came back with a little disturbance, some niggles.
“He wanted to play against Leicester, where he made an extraordinary game, but after that game his niggles were worse and we did not want to take a risk.
“Both are not able to play. I don’t know [if they will play] against Wycombe or Chelsea but hopefully they can be ready after. Right now, I don’t know.”